The Minnesota NeuroSpin Initiative is pleased to invite you to its first seminar in a new series. On Feb 25, Professor Hui Ye, Loyola University Chicago, will discuss his recent work related to:
Neural Inhibition with Microscopic Magnetic Stimulation
Numerous neurological dysfunctions are characterized by undesirable nerve activity. By providing reversible nerve blockage, electric stimulation with implanted electrode holds promises in the treatment of these conditions. However, there are significant limitations to its application, including poor bio-compatibility and decreased efficacy during chronic implantation. Magnetic coil with miniature size can mitigate these problems, by coating it with biocompatible material for chronic implantation. However, it is unknown if miniature coils could be effective in blocking neural activity and axonal conductance and if so, what are the underlying mechanisms. Professor Her Ye's team reported that a submillimeter coil can reversibly blocked action potentials in the unmyelinated axons, and from the soma of the neuron. They used the marine mollusk Aplysia californica for the study. They also developed a multi-compartment model of Aplysia neuron that is under micro-coil stimulation. Simulation indicate that coil stimulation altered the activation dynamics of the sodium and potassium channels. With improved biocompatibility and capability of emitting high-frequency stimuli, micro coil provides an appearing alternative for electric blockage of neural activity and axonal conductance at clinical settings.
Seminar Details
Seminar Host
- Prof. Jian-Ping Wang, University of Minnesota
Seminar Speaker
- Prof. Hui Ye, Loyola University Chicago
Date and Time
- February 25, 2022
- 11:30am-12:30pm CT
Location
Virtual Via Zoom - Link will be provided upon registration